Glycine → 6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-carboamide

HRID 894196ノート

反応式

HRID 894196 の反応式
Cl[C:2]([C:4]1[CH:19]=[CH:18][C:7]2[O:8][CH2:9][C:10]3[CH:17]=[CH:16][CH:15]=[CH:14][C:11]=3[C:12](=[O:13])[C:6]=2[CH:5]=1)=[O:3].[NH2:20]CC(O)=O>C(OCC)(=O)C>[O:13]=[C:12]1[C:11]2[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=2[CH2:9][O:8][C:7]2[CH:18]=[CH:19][C:4]([C:2]([NH2:20])=[O:3])=[CH:5][C:6]1=2

参加物

4

反応物 2

HCID 750GlycineHCID 134560052-Chlorocarbonyl-6,11-dihydro-11-oxodibenz[b,e]oxepin

生成物 1

HCID 124468236,11-Dihydro-11-oxodibenz[b,e]oxepin-2-carboamide

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Reflux 1.0 gm of 2-chlorocarbonyl-6,11-dihydro-11-oxodibenz[b,e]oxepin in 20 cc of ethyl acetate containing 2.0 gm of glycine for 5 hours. Evaporate the mixture to dryness. Add 30 cc of water to the solid residue and stir at room temperature for one hour. Separate the solid by filtration and recrystallize from ethanol to obtain the title product.

後処理

  1. customEvaporate the mixture to dryness
  2. additionAdd 30 cc of water to the solid residue
  3. customSeparate the solid
  4. filtrationby filtration
  5. customrecrystallize from ethanol

出典と根拠

ORDレコード
ord-d38d92c749664713907e853bf6c5d659
出典データセット
uspto-grants-1981_08
特許番号
US04282365

反応ノート

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