反応式
[NH2:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[O:9][CH3:10].[C:11](OC(=O)C)(=[O:13])[CH3:12].Cl>O>[CH3:12][C:11]([NH:8][C:6]1[CH:5]=[CH:4][C:3]([O:9][CH3:10])=[C:2]([NH2:1])[CH:7]=1)=[O:13]参加物
5
実験手順
Other aqueous processes of acylation have been taught to yield the single desired isomer compound I where R is --CH3 and --XR1 is --COCH3, but at lower yield. German 1,543,625, Example 1, teaches the acylation of freshly-distilled 2,4-diaminoanisole with acetic anhydride in water solution, without the addition of hydrochloric acid, to give 3-amino-4-methoxyacetanilide in 75% yield before recrystallization. Publication, Board of Federal Intelligence Agency, P.B. 74 051, p. 33 teaches a similar conversion of 2,4-diaminoanisole to 2-amino-4-acetamidoanisole, in aqueous solution, with acetic anhydride, in the presence of magnesia at 65% yield.
後処理
- customat lower yield
出典と根拠
- ORDレコード
- ord-8d2cfeabcbce45d1ba862323d484a9ef
- 出典データセット
- uspto-grants-1981_08
- 特許番号
- US04283556
関連ノート
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