2,6-Dimethylaniline → HCID 20512447、化合物

反応式

[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([NH:9][CH2:10][CH:11]([NH:13][C:14]2[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][C:15]=2[CH3:21])[CH3:12])[CH:6]=[CH:7][CH:8]=1.ClC(C)[CH2:26][NH:27]C1C=CC=C(C(F)(F)F)C=1.CC1C=CC=C(C)C=1N.Cl.CC1C=CC=C(C)C=1N>>[F:1][C:2]([F:22])([F:23])[C:3]1[CH:4]=[C:5]([N:9]2[CH2:10][CH:11]([CH3:12])[N:13]([C:14]3[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][C:15]=3[CH3:21])[C:26]2=[NH:27])[CH:6]=[CH:7][CH:8]=1

参加物

反応物 4

HCID 68962,6-Dimethylaniline

HCID 88899Benzenamine, 2,6-dimethyl-, hydrochloride (1:1)

HCID 20512435HCID 20512435、化合物

HCID 70580401HCID 70580401、化合物

生成物 1

HCID 20512447HCID 20512447、化合物収率 55.6%

実験手順

1-(3'-Trifluoromethylphenyl-amino)-2-(2',6'-dimethylphenyl-amino)-propane, applied as starting substance, is prepared by reacting N-(β-chloropropyl)-3-trifluoromethylaniline, a compound obtained as described in Example 23, point (b), with 2,6-dimethylaniline. The reaction is performed as described in Example 16, point (c) with the difference that crystalline 2,6-dimethylaniline hydrochloride is separated from the reaction mixture by trituration with ethyl acetate. The aimed product is obtained with a yield of 55.6%; m.p.: 95°-98° C. (dhydrochloride).