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Triethylamine → N-(3'-Cyclohexylaminopropyl)-aspartic acid-4-cyclohexyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | N-Cyclohexyl-1,3-propanediamine | HCID 18718 | — |
| 反応物 | 1-Cyclohexyl (2Z)-2-butenedioate | HCID 6913007 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | N-(3'-Cyclohexylaminopropyl)-aspartic acid-4-cyclohexyl ester | HCID 86737947 | 85.2% |
反応手順
400 ml of triethylamine are added dropwise to a solution of 433.8 g (2 mols+10% excess) of maleic acid-monocyclohexyl ester and 200 ml of dioxane, in a manner analogous to that of Example 1, and the mixture is then reacted with 310.5 g (2.0 mols) of 3-cyclohexylamino-1-propylamine for 40 minutes at 70°-90° C. The reaction mixture is further processed as in Example 1 to yield 604 g (85.2% of theory) of a white crystalline aspartic acid derivative, which decomposes at 172°-173° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04284755 |
| 出典データセット | uspto-grants-1981_08 |
| ORD ID | ord-35523bce96ea474c9fe23c2b1fd0159f |
| 出典メモ | uspto-grants-1981_08 |