化工社化工社 化学情報印刷レポート · 研究参考用
Phosphorisocyanatidic dichloride → Cefuroxime
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorisocyanatidic dichloride | HCID 70090 | — |
| 反応物 | (6R,7R)-7-(((2Z)-2-(2-Furanyl)-2-(methoxyimino)acetyl)amino)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid | HCID 9800056 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | Cefuroxime | HCID 5479529 | 56.7% |
反応手順
The process of Example 3 was repeated, using dichlorophosphinyl isocyanate (1.46 ml) and a solution of (6R,7R)-7-[Z-2-(fur-2-yl)-2-methoxyiminoacetamido]-3hydroxymethylceph-3-em-4-carboxylic acid (3.81 g) in acetone (50 ml) cooled to 4°, but the reaction mixture was heated at 45° for 2 hours and then kept at 20° overnight, to give the title compound (2.40 g, 56.7%); purity by HPLC 95.6% and by TLC 94.5%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04284767 |
| 出典データセット | uspto-grants-1981_08 |
| ORD ID | ord-1c61885a5b8b4ff480bd40d166cecdaa |
| 出典メモ | uspto-grants-1981_08 |