Hydrochloric Acid → EN 272
反応式
[F:1][CH:2]([F:22])[N:3]1[C:12]2[C:7](=[CH:8][C:9]3[O:15][CH2:14][O:13][C:10]=3[CH:11]=2)[C:6](=[O:16])[C:5]([C:17]([O:19]CC)=[O:18])=[CH:4]1.Cl>O>[F:22][CH:2]([F:1])[N:3]1[C:12]2[C:7](=[CH:8][C:9]3[O:15][CH2:14][O:13][C:10]=3[CH:11]=2)[C:6](=[O:16])[C:5]([C:17]([OH:19])=[O:18])=[CH:4]1参加物
4
実験手順
A mixture of 27.5 g of 1-difluoromethyl-6,7-methylenedioxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, ethyl ester and 600 ml of 6 N hydrochloric acid is heated under reflux for 1.5 hours. The mixture is diluted with 1 liter of water, cooled, and filtered. The solid product is triturated with cold ethanol and filtered to give 24.5 g of the desired product, m.p. 327°-8° C. (dec). Anal. Calc'd for C12H7F2O5 ; C:50.89, H:2.49, N:4.95--Found; C:50.95, H:2.54, N:4.84.
後処理
- temperatureis heated
- temperatureunder reflux for 1.5 hours
- temperaturecooled
- filtrationfiltered
- customThe solid product is triturated with cold ethanol
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-6fcf0860f15643ada53d203a30c32bc3
- 出典データセット
- uspto-grants-1981_08
- 特許番号
- US04284777
反応ノート
読み込み中…