Diethyl Ether → 2-(3-Methoxyphenyl)-2-methyloxirane

HRID 894918ノート

反応式

HRID 894918 の反応式
[CH3:1]S(C)(=O)=C.CO[CH:8](OC)[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10].C[CH2:20][O:21]CC>CS(C)=O.O>[CH3:20][O:21][C:15]1[CH:16]=[C:11]([CH:12]=[CH:13][CH:14]=1)[C:9]1([CH3:8])[O:10][CH2:1]1

参加物

6

反応物 3

HCID 3283Diethyl EtherHCID 2483332,2-Dimethoxy-1-phenylethanoneHCID 6396768Dimethylsulfoxonium methylide

生成物 1

HCID 204969162-(3-Methoxyphenyl)-2-methyloxirane

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

To a solution of dimethylsulfoxonium methylide (69.4 mmoles) in dimethyl sulfoxide (65 ml.) at room temperature is added solid 3-l -dimethoxyacetophenone (8.33 g., 55.5 mmoles). The reaction mixture is stirred for one hour at 25° C., for one-half hour at 50° C. and is then cooled. The mixture is diluted with water (50 ml.) and added to a mixture of ice water (200 ml.)--ether (250 ml.)--low boiling petroleum ether (25 ml.). The organic extract is washed twice with water (250 ml.), dried (MgSO4) and evaporated to an oil which is fractionally distilled.

後処理

  1. temperatureis then cooled
  2. extractionThe organic extract
  3. washis washed twice with water (250 ml.)
  4. dry with materialdried (MgSO4)
  5. customevaporated to an oil which
  6. distillationis fractionally distilled

出典と根拠

ORDレコード
ord-23b5d1020e8f4ab59f87e7356365424b
出典データセット
uspto-grants-1981_08
特許番号
US04284829

反応ノート

読み込み中…