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2-Methoxy-6-(4-methoxyphenyl)naphthalene → 6-(4-Hydroxyphenyl)-2-naphthol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methoxy-6-(4-methoxyphenyl)naphthalene | HCID 11149734 | — |
| 反応物 | Pyridinium hydrochloride | HCID 21584435 | — |
| 生成物 | 6-(4-Hydroxyphenyl)-2-naphthol | HCID 11459006 | 98% |
反応手順
2-Methoxy-6-(4-methoxyphenyl)naphthalene (5.61 g, 21.2 mmol) was added to pyridinium HCl (30 g) at 190° C. according to Method B to afford 4.88 g (98%) of a white solid: mp>220 (discolors above 200° C.); 1H NMR (DMSO-d6): δ 6.87 (2H, d, J=8.54 Hz), 7.08 (1H, dd, J=2.34 Hz, J=8.76 Hz), 7.11 (1H, d, J=2.14 Hz), 7.58 (2H, d, J=8.54 Hz), 7.65 (1H, dd, J=1.92 Hz, J=8.76 Hz), 7.71 (1H, d, J=8.54 Hz), 7.79 (1H, d, J=8.97 Hz), 7.95 (1H, s), 9.56 (1H, bs), 9.70 (1H, bs); MS (ESI) m/z 235 (M−H)−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06914074B2 |
| 出典データセット | uspto-grants-2005_07 |
| ORD ID | ord-0969c2caeefb4771b215333c558824d7 |
| 出典メモ | uspto-grants-2005_07 |