Triethylamine → 2-(2-Bromomethyl-benzyloxy)-isoindole-1,3-dione

HRID 8953

反応式

HRID 8953 の反応式
[OH:1][N:2]1[C:6](=[O:7])[C:5]2=[CH:8][CH:9]=[CH:10][CH:11]=[C:4]2[C:3]1=[O:12].CCN(CC)CC.[Br:20][CH2:21][C:22]1[C:23]([CH2:28]Br)=[CH:24][CH:25]=[CH:26][CH:27]=1>CN(C=O)C>[Br:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[CH2:28][O:1][N:2]1[C:3](=[O:12])[C:4]2[C:5](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]1=[O:7]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 10665N-HydroxyphthalimideHCID 66665o-Bis(bromomethyl)benzene

生成物 1

HCID 219851622-(2-Bromomethyl-benzyloxy)-isoindole-1,3-dione収率 46%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a stirred solution of N-hydroxyphthalimide (0.60 g, 3.68 mmol) and Et3N (0.60 mL, 4.30 mmol) in DMF (6 mL) was added α,α′-dibromo-o-xylene (3.30 g, 0.0125 mol) and the mixture stirred at room temperature for 4 h. The resultant brown precipitate was filtered and washed with CH2Cl2. The filtrate was diluted with EtOAc (40 mL) and water (30 mL) and the organic phase washed with brine (1×30 mL), dried (Na2SO4) and concentrated under reduced pressure. The resultant yellow oil was purified by column chromatography on silica gel (4:1 Hexanes/EtOAc) to give the title compound (581 mg, 46%) as a white solid. 1H NMR (CDCl3) δ 4.99 (s, 2H), 5.37 (s, 2H), 7.27–7.40 (m, 2H), 7.41–7.45 (m, 2H), 7.73–7.76 (m, 2H), 7.81–7.84 (m, 2H).

後処理

  1. filtrationThe resultant brown precipitate was filtered
  2. washwashed with CH2Cl2
  3. additionThe filtrate was diluted with EtOAc (40 mL) and water (30 mL)
  4. washthe organic phase washed with brine (1×30 mL)
  5. dry with materialdried (Na2SO4)
  6. concentrationconcentrated under reduced pressure
  7. customThe resultant yellow oil was purified by column chromatography on silica gel (4:1 Hexanes/EtOAc)

出典と根拠

ORDレコード
ord-08381d0f80044bf994b13f6803c6eb40
出典データセット
uspto-grants-2006_08
特許番号
US07091217B2

関連ノート

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