4-(2-Methoxy-5-nitrophenyl)morpholine → 4-Methoxy-3-morpholin-4-yl-phenylamine
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][C:4]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][C:4]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1参加物
3
実験手順
4-(2-Methoxy-5-nitro-phenyl)-morpholine (w, 390 mg) was dissolved in 10 mL ethanol and reduced under 1 atm H2 using 10% Pd—C as a catalyst. After 14 hours, the catalyst was filtered off and the solvent was evaporated, affording 240 mg 4-methoxy-3-morpholin-4-yl-phenylamine (x) which was used without further purification: m/e: 208.12, MS (ES+): 209.2.
後処理
- filtrationthe catalyst was filtered off
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-8b8b71003eb245fd8d69561c19b6ada7
- 出典データセット
- uspto-grants-2005_07
- 特許番号
- US06916798B2
反応ノート
読み込み中…