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Diisopropylethylamine → N-(6-Chloro-2-phenylpyrimidin-4-yl)-2-{4-[(2E)-3-phenylprop-2-enyl]piperazin-1-yl}acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 1-Cinnamylpiperazine | HCID 726896 | — |
| 反応物 | 2-bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide | HCID 22379151 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | N-(6-Chloro-2-phenylpyrimidin-4-yl)-2-{4-[(2E)-3-phenylprop-2-enyl]piperazin-1-yl}acetamide | HCID 22353283 | — |
反応手順
To a stirred solution of 2-bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide (0.80 g in 40 ml acetonitrile) was added [(2E)-3-phenylprop-2-enyl]piperazine (0.50 g in 10 ml acetonitrile). After 3 hrs, N,N-diisopropylethylamine was added (428 μl in 10 ml acetonitrile) and the reaction stirred for a further 2 hrs after which time a precipitate of the title compound appeared. This was used crude in the next step. m/z (ES+) 448 (MH)+
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06916804B2 |
| 出典データセット | uspto-grants-2005_07 |
| ORD ID | ord-2caf9f5569a94b57b0611000b20f0ee6 |
| 出典メモ | uspto-grants-2005_07 |