Potassium Hydroxide → 4-Ethinyl-1,5-dimethyl-3-(trifluoromethyl)-1h-pyrazole
反応式
Br[CH:2]([C:5]1[C:6]([C:12]([F:15])([F:14])[F:13])=[N:7][N:8]([CH3:11])[C:9]=1[CH3:10])[CH2:3]Br.[OH-].[K+]>C1(C)C=CC=CC=1>[C:2]([C:5]1[C:6]([C:12]([F:14])([F:15])[F:13])=[N:7][N:8]([CH3:11])[C:9]=1[CH3:10])#[CH:3]参加物
4
実験手順
7.3 g (20.9 mmol) of 4-(1,2-dibromoethyl)-1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazole are taken up in 5 ml of toluene and heated to 70° C. for 12 h together with a 60% aqueous KOH solution (10 ml) and 1.2 g of polyethylene glycol 600. After the end of the reaction, the two phases are separated, the aqueous phase is extracted with toluene and the combined organic phases are dried over MgSO4 and concentrated. The product is obtained as a solid in an 81% yield.
後処理
- customAfter the end of the reaction
- customthe two phases are separated
- extractionthe aqueous phase is extracted with toluene
- dry with materialthe combined organic phases are dried over MgSO4
- concentrationconcentrated
- customThe product is obtained as a solid in an 81% yield
出典と根拠
- ORDレコード
- ord-2deab906e34649328e8697086aeb03d8
- 出典データセット
- uspto-grants-2005_07
- 特許番号
- US06916839B2
反応ノート
読み込み中…