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Acetic Acid → 1-Benzyl-4-phenylpiperidine-4-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 1-Benzyl-4-cyano-4-phenylpiperidine | HCID 191408 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-Benzyl-4-phenylpiperidine-4-carboxamide | HCID 96423 | — |
反応手順
(a′) 1-benzyl-4-cyano-4-phenylpiperidine, prepared in situ via neutralization of its hydrochloride, is treated with 94-96% sulfuric acid and acetic acid in toluene at 80-100° C. and the 1-benzyl-4-phenyl-4-piperidinecarboxamide thus obtained is treated with bromine in the presence of sodium methoxide; and then
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06916929B2 |
| 出典データセット | uspto-grants-2005_07 |
| ORD ID | ord-724d21cdd37c4afd8037ad128005f9e1 |
| 出典メモ | uspto-grants-2005_07 |