関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | 3-(4-Methoxyphenyl)prop-2-enenitrile | HCID 34240 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 3-(4-Methoxyphenyl)prop-2-enal | HCID 230995 | 35% |
反応手順
To 2 g (12.6 mmol) 4-methoxycinnamonitrile in 10:10:20 ml H2O:HOAc:pyridine was added 5 g (47 mmol) NaH2PO2 (hypophosphite) followed by 2 g RaNi. After stirring 3 hours at 50° C., the reaction mixture was filtered, extracted with CH2Cl2, washed with dilute HCl, washed with H2O and evaporated to give 0.7 g (35% yield) 4-methoxycinnamaldehyde, a yellow solid, m.p. 47° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | USRE038761E1 |
|---|
| 出典データセット | uspto-grants-2005_07 |
|---|
| ORD ID | ord-69f1bb31c39f41839482b13f761928dd |
|---|
| 出典メモ | uspto-grants-2005_07 |
|---|
