Dimethylamine → 5-Bromo-2,3-dihydro-N,N-dimethyl-1H-inden-1-amine

HRID 896072ノート

反応式

HRID 896072 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7](Cl)[CH2:6][CH2:5]2.[CH3:12][NH:13][CH3:14]>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7]([N:13]([CH3:14])[CH3:12])[CH2:6][CH2:5]2

参加物

4

反応物 2

HCID 674DimethylamineHCID 223495155-Bromo-1-chloro-2,3-dihydro-1H-indene

生成物 1

HCID 223495485-Bromo-2,3-dihydro-N,N-dimethyl-1H-inden-1-amine収率 53%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
90 °C

実験手順

To a solution of 5-bromo-1-chloro-indane (542 mg, 2.35 mmol) in toluene (9 ml) was added dimethylamine (3 ml) and resulting mixture was heated at 90° C. for 1.5 hr. The reaction mixture is concentrated under reduced pressure to yield the title compound (300 mg, 53%). 1H NMR (CDCl3): 2.06 (m, 2H), 2.24 (s, 6H), 2.81-2.93 (m, 2H), 4.27 (t, 1H), 7.22 (d, 1H), 7.33 (d 1H), 7.36 (s, 1H).

後処理

  1. customresulting mixture
  2. concentrationThe reaction mixture is concentrated under reduced pressure

出典と根拠

ORDレコード
ord-6812c9fe88d24300b655f476ca265438
出典データセット
uspto-grants-2005_07
特許番号
US06919335B2

反応ノート

読み込み中…