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HRID 896086作成日：2026年10月26日

2-(Methylthio)-4-(tributylstannyl)pyrimidine → [6-(2,4-Difluoro-phenylamino)-pyridin-3-yl]-[2-methoxy-5-(2-methylsulfanyl-pyrimidin-4-yl)-phenyl]-methanone

https://huagongshe.com/reaction/896086

反応式

関与物質

役割名称HCID仕込み量
反応物2-(Methylthio)-4-(tributylstannyl)pyrimidineHCID 2763261—
反応物(5-Bromo-2-methoxy-phenyl)-[6-(2,4-difluoro-phenylamino)-pyridin-3-yl]-methanoneHCID 22349594—
生成物[6-(2,4-Difluoro-phenylamino)-pyridin-3-yl]-[2-methoxy-5-(2-methylsulfanyl-pyrimidin-4-yl)-phenyl]-methanoneHCID 2234958045%

反応手順

[6-(2,4-Difluoro-phenylamino)-pyridin-3-yl]-[2-methoxy-5-(2-methylsulfanyl-pyrimidin-4-yl)-phenyl]-methanone is prepared in analogy to example 11 from (5-bromo-2-methoxy-phenyl)-[6-(2,4-difluoro-phenylamino)-pyridin-3-yl]-methanone and 2-methylsulfanyl-4-tributylstannanyl-pyrimidine in 45% yield:

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06919336B2
出典データセットuspto-grants-2005_07
ORD IDord-1eebe55b109b43398c3ca6b4e770e79f
出典メモuspto-grants-2005_07