化工社化工社 化学情報印刷レポート · 研究参考用
2-Nitrobenzenesulfonyl chloride → N-cyclopropyl-2-nitrobenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Nitrobenzenesulfonyl chloride | HCID 15540 | — |
| 反応物 | Cyclopropylamine | HCID 69828 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-cyclopropyl-2-nitrobenzenesulfonamide | HCID 796630 | 88% |
反応手順
To a −78° C. mixture of cyclopropylamine (10 g, 1.75 mmol) in CH2Cl2 (100 mL) was added a solution of 2-nitrobenzene sulfonyl chloride (22.1 g, 85.7 mmol) and the mixture was stirred for 12 h. The mixture was washed with 1N HCl dried over MgSO4 then concentrated to give 18.7 g, (88%) of a N-Cyclopropyl-2-nitro-benzenesulfonamide as a tan solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06919331B2 |
| 出典データセット | uspto-grants-2005_07 |
| ORD ID | ord-56ffc089fbf04dcbbaa076fcefc8b31e |
| 出典メモ | uspto-grants-2005_07 |