2-Nitrobenzenesulfonyl chloride → N-cyclopropyl-2-nitrobenzenesulfonamide

HRID 896348

反応式

HRID 896348 の反応式
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.[N+:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[S:14](Cl)(=[O:16])=[O:15])([O-:7])=[O:6]>C(Cl)Cl>[CH:1]1([NH:4][S:14]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[N+:5]([O-:7])=[O:6])(=[O:15])=[O:16])[CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 155402-Nitrobenzenesulfonyl chlorideHCID 69828Cyclopropylamine

生成物 1

HCID 796630N-cyclopropyl-2-nitrobenzenesulfonamide収率 88%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a −78° C. mixture of cyclopropylamine (10 g, 1.75 mmol) in CH2Cl2 (100 mL) was added a solution of 2-nitrobenzene sulfonyl chloride (22.1 g, 85.7 mmol) and the mixture was stirred for 12 h. The mixture was washed with 1N HCl dried over MgSO4 then concentrated to give 18.7 g, (88%) of a N-Cyclopropyl-2-nitro-benzenesulfonamide as a tan solid.

後処理

  1. washThe mixture was washed with 1N HCl
  2. dry with materialdried over MgSO4
  3. concentrationthen concentrated

出典と根拠

ORDレコード
ord-56ffc089fbf04dcbbaa076fcefc8b31e
出典データセット
uspto-grants-2005_07
特許番号
US06919331B2

関連ノート

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