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Hydrochloric Acid → 2-Amino-N-cyclopropylbenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | N-cyclopropyl-2-nitrobenzenesulfonamide | HCID 796630 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Amino-N-cyclopropylbenzenesulfonamide | HCID 16793378 | 98.5% |
反応手順
A solution of N-cyclopropyl-2-nitro-benzenesulfonamide (7.9 g, 33.0 mmol) in EtOH (50 ml) was treated with HCl (3.0 ml, 4.0 N in dioxane), Pd/C (10%, 100 mg) and shaken in a Parr Hydrogenator at 50 psi for 48 h. The catalyst was removed by filtration and the solvent evaporated to give 6.9 g (84%) of 2-Amino-N-cyclopropyl-benzenesulfonamide as a light grey solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06919331B2 |
| 出典データセット | uspto-grants-2005_07 |
| ORD ID | ord-11c07d3686654430a629bd130ea97501 |
| 出典メモ | uspto-grants-2005_07 |