化工社化工社 化学情報印刷レポート · 研究参考用
Tetramethylammonium hydroxide → Lipoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetramethylammonium hydroxide | HCID 60966 | — |
| 反応物 | (R)-Dihydrolipoic acid | HCID 9834298 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Lipoic acid | HCID 6112 | — |
| 生成物 | (R)-Dihydrolipoic acid | HCID 9834298 | — |
反応手順
In other synthetic schemes the base, tetramethylammonium hydroxide can be substituted for potassium t-butoxide in DMF. The former base though can be stored under air, whilst the latter needs to be kept in an inert atmosphere. The dihydrolipoic acid works best if it totally clear. If the reduction lipoic acid to produce dihydrolipoic acid is not complete, a yellow coloration of the solution will be evident. The yellow solution can be distilled (distills at 140° C. under vacuum) to yield a clear solution of dihydrolipoic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06921496B2 |
| 出典データセット | uspto-grants-2005_07 |
| ORD ID | ord-dfa8a8fbcaf8412da0e392ebd82dc423 |
| 出典メモ | uspto-grants-2005_07 |