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Tetrahydrofuran → Ethyl 3-phenyl-5-trimethylsilanylpent-2-en-4-ynoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Trimethylsilylacetylene | HCID 66111 | — |
| 反応物 | Phenylpropynoic acid methyl ester | HCID 138378 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 生成物 | Ethyl 3-phenyl-5-trimethylsilanylpent-2-en-4-ynoate | HCID 86142661 | — |
反応手順
A solution of TDMPP (1.4 g) and palladium acetate (700 mg) in THF (200 ml) is stirred for 15 min at room temperature and methyl phenylpropiolate (10 g, 62.5 mmol) is then added. The reaction medium is stirred for 5 min at room temperature and trimethyl-silylacetylene (87.5 mmol) is then added. Stirring is continued overnight at room temperature. The reaction medium is concentrated and filtered through silica.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06921777B2 |
| 出典データセット | uspto-grants-2005_07 |
| ORD ID | ord-61eae75c5d7947aeb1d138ab049b4db4 |
| 出典メモ | uspto-grants-2005_07 |