Sodium Bicarbonate → N-(2,2-Diphenylethyl)-2-(methylsulphonyl)-9-tetrahydro-2H-pyran-2-yl-9H-purin-6-amine

A solution of Oxone (Trade Mark) (potassium peroxymonosulphate) (44 g, 71.7 mmol) in water (200 ml) was added dropwise over 2 hours to a solution of N-(2,2-diphenylethyl)-2-(methylsulfanyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (Preparation 21) (25 g, 56.2 mmol) and sodium hydrogencarbonate (20 g, 238 mmol) in a mixture of acetone (1000 ml) and water (250 ml). The resultant mixture was stirred at room temperature for 24 hours and filtered and the residue was washed with acetone. The acetone was removed from the filtrate under reduced pressure and the resulting aqueous residue was extracted with ethyl acetate and then dichloromethane. The combined organic layers were washed with brine, dried over anhydrous magnesium sulphate, filtered and evaporated under reduced pressure. The residue was triturated with diethyl ether, filtered, washed with diethyl ether and pentane and then dried to afford the title compound as a white solid (20.32 g).

1. filtrationfiltered
2. washthe residue was washed with acetone
3. customThe acetone was removed from the filtrate under reduced pressure
4. extractionthe resulting aqueous residue was extracted with ethyl acetate
5. washThe combined organic layers were washed with brine
6. dry with materialdried over anhydrous magnesium sulphate
7. filtrationfiltered
8. customevaporated under reduced pressure
9. customThe residue was triturated with diethyl ether
10. filtrationfiltered
11. washwashed with diethyl ether and pentane
12. customdried

ORDレコード

ord-631fbe08632947368db90673af5a062a

出典データセット

uspto-grants-2005_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06921753B2