(S)-2,3-epoxy-2-trifluoromethylpropionic acid benzyl ester → HCID 10464546、化合物

HRID 897165ノート

反応式

HRID 897165 の反応式
C([O:8][C:9](=[O:17])[C@@:10]1([C:13]([F:16])([F:15])[F:14])[O:12][CH2:11]1)C1C=CC=CC=1.[H][H]>[Pt]=O.CO>[O:12]1[CH2:11][C@@:10]1([C:13]([F:16])([F:15])[F:14])[C:9]([OH:17])=[O:8]

参加物

5

反応物 2

HCID 10014785(S)-2,3-epoxy-2-trifluoromethylpropionic acid benzyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 10464546HCID 10464546、化合物収率 90%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 887Methanol溶媒

実験手順

Into a 500 ml three-necked round-bottomed flask equipped with a stirrer, (S)-2,3-epoxy-2-trifluoromethylpropionic acid benzyl ester (20.9 g, 84.9 mmol, 99 ee %) was charged, and 180 ml of methanol was added for dissolution. Platinum oxide (1.63 g) was added, and then, the reaction system was substituted by hydrogen. After stirring at room temperature for 4 hours, platinum oxide was filtered off. The solvent was distilled off under reduced pressure, whereupon (S)-2,3-epoxy-2-trifluoromethylpropionic acid (11.9 g) was obtained (yield: 90%).

後処理

  1. customInto a 500 ml three-necked round-bottomed flask equipped with a stirrer
  2. filtrationplatinum oxide was filtered off
  3. distillationThe solvent was distilled off under reduced pressure, whereupon (S)-2,3-epoxy-2-trifluoromethylpropionic acid (11.9 g)
  4. customwas obtained (yield: 90%)

出典と根拠

ORDレコード
ord-ee5de33be4fd47aa995c76b52ed103ef
出典データセット
uspto-grants-2005_07
特許番号
US06921832B2

反応ノート

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