Methanol → HCID 22348438、化合物
反応式
C(O[C:4](=[O:17])[CH2:5][C:6]1([CH2:13][N+]([O-])=O)[CH2:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7]1)C.[CH3:18]O>[Ni]>[CH3:12][C:8]1([CH3:11])[CH2:9][CH2:10][C:6]2([CH2:5][C:4](=[O:17])[CH2:18][CH2:13]2)[CH2:7]1参加物
4
実験手順
The ester 3 (380 mg, 1.6 mmol) and Raney Nickel (1 g) were suspended in methanol (75 mL) and shaken under a hydrogen atmosphere for 24 hours. The catalyst was removed by filtration, the filtrate concentrated to give the lactam 4 (246 mg, 94%) as a white solid.
後処理
- customThe catalyst was removed by filtration
- concentrationthe filtrate concentrated
出典と根拠
- ORDレコード
- ord-b9d7611269f7434a9e222d63b4205ef7
- 出典データセット
- uspto-grants-2005_07
- 特許番号
- US06921835B2
反応ノート
読み込み中…