2-Methylcinnamic aldehyde → 6-Chloro-4-[1-(2-methyl-3-phenyl-allyl)-piperidin-4-ylamino]-chromen-2-One

関与物質

反応手順

According to Procedure A above, 6-chloro-4-(piperidin-4-ylamino)-chromen-2-one and 2-methyl-3-phenyl-propenal (0.031 g, 0.216 mmol) were allowed to react to give the title compound (0.008 g, 25.8%, mono-TFA salt) as a off-white solid. 1H NMR (400 MHz, DMSO) δ ppm 8.35 (d, J=3, 1H), 7.66 (dd, J=3, 9, 1H), 7.32-7.47 (m, 6H), 6.76 (br s, 1H), 5.46 (s, 1H), 3.94-3.99 (m, 1H), 3.86 (d, J=3, 9, 1H), 3.53-3.60 (m, 2H), 3.05-3.20 (m, 2H), 2.18-2.28 (m, 2H), 2.05-2.15 (m, 1H), 2.01 (s, 3H), 1.82-1.91 (m, 2H); MS (ESI+Q1MS) m/z 409 [M]+

情報源と証拠