Diethyl Ether → HCID 22346251、化合物

反応式

C([O:9][C:10]1[C:19]2[N:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:13]([C:20]([O:22][CH3:23])=[O:21])=[N:12][C:11]=1[C:24]([O:26][CH3:27])=[O:25])(=O)C1C=CC=CC=1.C(N)C1C=CC=CC=1.C(OCC)C>CO>[OH:9][C:10]1[C:19]2[N:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:13]([C:20]([O:22][CH3:23])=[O:21])=[N:12][C:11]=1[C:24]([O:26][CH3:27])=[O:25]

参加物

反応条件

温度: 80 °C

実験手順

Dimethyl 8-(benzoyloxy)-1,6-naphthyridine-5,7-dicarboxylate (2.0 g, 5.46 mmol, prepared as in Example 164) was dissolved in dry methanol (4.0 ml) in a pressure tube. Benzylamine (0.58 g, 5.46 mmol) was added and the reaction capped and heated to 80 degrees C. under nitrogen for 16 hours. LCMS analysis indicated that the reaction was complete. The reaction was transferred to an Erlenmeyer flask and then diethyl ether was added to precipitate the product. Filtered and dried the solid in vacuo to obtain the desired compound.