4-Bromoaniline → 1-(4-Bromoanilino)-3-phenyl-2-propanol

HRID 897626

反応式

HRID 897626 の反応式
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[O:9]1[CH2:18][CH:10]1[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CO>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH2:18][CH:10]([OH:9])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 78074-BromoanilineHCID 948262-(Phenylmethyl)oxirane

生成物 1

HCID 223472001-(4-Bromoanilino)-3-phenyl-2-propanol収率 70.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 4-bromoaniline (1.75 g, 0.0102 mol) and 2,3-epoxy-propylbenzene (1.77 g, 0.0132 mol) in methanol (40 mL) was heated at reflux for 16 hours. The mixture was cooled to ambient temperature and concentrated under reduced pressure. The residue was purified by flash chromatography on silica using ethyl acetate/n-heptane (1:5) as mobile phase to yield 1-(4-bromoanilino)-3-phenyl-2-propanol (2.2 g, 0.00719 mol) as a colorless oil.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 16 hours
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was purified by flash chromatography on silica

出典と根拠

ORDレコード
ord-a1d99133df9c49e5934ae015ef333b4c
出典データセット
uspto-grants-2005_07
特許番号
US06921763B2

関連ノート

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