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HRID 898157作成日：2026年10月26日
Water → 3-(4-Bromobenzyl)-8-(3,3-diphenyl-propyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione Hydrochloride
https://huagongshe.com/reaction/898157
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1,1'-(3-Bromopropylidene)bisbenzene | HCID 88333 | — |
| 反応物 | 3-(4-Bromo-benzyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione hydrochloride | HCID 69207577 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-(4-Bromobenzyl)-8-(3,3-diphenyl-propyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione Hydrochloride | HCID 69207606 | 32.1% |
反応手順
A mixture of 26.2 mg (70 μmol) of 3-(4-bromo-benzyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione hydrochloride, 21.4 mg (70 μmol) of 3,3-diphenylpropyl bromide and 29 mg (210 μmol) of potassium carbonate in 1 mL of anhydrous DMF was heated overnight at 60° C. After cooling to room temperature, 0.5 mL of water was added and the solution was extracted with DCM (2×2 mL). The crude material was purified by semi-preparative HPLC (method A) yielding 12.8 mg (32.1%) of Compound 3 as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07351713B2 |
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| 出典データセット | uspto-grants-2008_04 |
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| ORD ID | ord-a6288280573245c68b10df567eb51a5b |
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| 出典メモ | uspto-grants-2008_04 |
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