6-Methoxy-2-naphthaldehyde → 6-Hydroxy-2-naphthaldehyde
反応式
[Cl-].[Cl-].[Cl-].[Al+3].C[O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([CH:17]=[O:18])[CH:11]=[CH:10]2>ClC1C=CC=CC=1>[OH:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([CH:17]=[O:18])[CH:11]=[CH:10]2参加物
4
反応条件
- 温度
- 130 °C
実験手順
Aluminum trichloride (1.07 g, 8.06 mmol) was added to a solution of 6-methoxy-2-naphthaldehyde (1.0 g, 5.37 mmol) in chlorobenzene (15 mL). The reaction mixture was stirred at 130° C. for 4 h. The reaction was quenched with water (5 mL) and conc. HCl (2 mL). The reaction mixture was dissolved in ethyl acetate and washed with water and brine and dried over anhydrous magnesium sulfate. Silica gel chromatography eluting with 10% ethyl acetate/hexane yielded 0.35 g of desired product: ESI-MS173.0 (M+H).
後処理
- customThe reaction was quenched with water (5 mL) and conc. HCl (2 mL)
- dissolutionThe reaction mixture was dissolved in ethyl acetate
- washwashed with water and brine
- dry with materialdried over anhydrous magnesium sulfate
- washSilica gel chromatography eluting with 10% ethyl acetate/hexane
出典と根拠
- ORDレコード
- ord-89c00d81e8fb4583825a73f1263c7bee
- 出典データセット
- uspto-grants-2008_04
- 特許番号
- US07351725B2
反応ノート
読み込み中…