6-Methoxy-2-naphthaldehyde → 6-Hydroxy-2-naphthaldehyde

HRID 898188

反応式

HRID 898188 の反応式
[Cl-].[Cl-].[Cl-].[Al+3].C[O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([CH:17]=[O:18])[CH:11]=[CH:10]2>ClC1C=CC=CC=1>[OH:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([CH:17]=[O:18])[CH:11]=[CH:10]2

参加物

4

反応物 2

HCID 769916-Methoxy-2-naphthaldehydeHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 27641106-Hydroxy-2-naphthaldehyde収率 37.9%

試薬・触媒・溶媒 1

HCID 7964Chlorobenzene溶媒

反応条件

温度
130 °C

実験手順

Aluminum trichloride (1.07 g, 8.06 mmol) was added to a solution of 6-methoxy-2-naphthaldehyde (1.0 g, 5.37 mmol) in chlorobenzene (15 mL). The reaction mixture was stirred at 130° C. for 4 h. The reaction was quenched with water (5 mL) and conc. HCl (2 mL). The reaction mixture was dissolved in ethyl acetate and washed with water and brine and dried over anhydrous magnesium sulfate. Silica gel chromatography eluting with 10% ethyl acetate/hexane yielded 0.35 g of desired product: ESI-MS173.0 (M+H).

後処理

  1. customThe reaction was quenched with water (5 mL) and conc. HCl (2 mL)
  2. dissolutionThe reaction mixture was dissolved in ethyl acetate
  3. washwashed with water and brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. washSilica gel chromatography eluting with 10% ethyl acetate/hexane

出典と根拠

ORDレコード
ord-89c00d81e8fb4583825a73f1263c7bee
出典データセット
uspto-grants-2008_04
特許番号
US07351725B2

関連ノート

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