化工社化工社 化学情報印刷レポート · 研究参考用
Benzyl Bromide → Ethyl alpha-benzylacetoacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Ethyl Acetoacetate | HCID 8868 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | Ethyl alpha-benzylacetoacetate | HCID 246929 | 74% |
反応手順
0.1 Mol of ethyl acetoacetate, 0.1 mol of K2CO3, 0.1 mol of benzyl bromide, 0.01 mmol of PEG-400 (polyethylene glycol 400) and 100 ml of benzene were stirred at 75° C. for 7 hours. After cooling, 20 ml of saturated solution of NH4Cl was added to dissolve solid, and product was extracted with ethyl acetate. After removing the solvent, the residue was distilled under reduced pressure, and a cut fraction was collected at 116-118° C./20 Pa. Yield 74%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07351778B2 |
| 出典データセット | uspto-grants-2008_04 |
| ORD ID | ord-e2405c4aecdd42af8025950385979ec4 |
| 出典メモ | uspto-grants-2008_04 |