Ethyl Acetoacetate → Isobutyl 3-hydroxybutanoate

反応式

[C:1]([O:7][CH2:8][CH:9]([CH3:11])[CH3:10])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].C(OCC)(=O)CC(C)=O>>[OH:4][CH:3]([CH3:5])[CH2:2][C:1]([O:7][CH2:8][CH:9]([CH3:11])[CH3:10])=[O:6]

参加物

反応物 2

HCID 8868Ethyl Acetoacetate

HCID 522677Isobutyl acetoacetate

生成物 1

HCID 529006Isobutyl 3-hydroxybutanoate収率 52%

実験手順

Isobutyl 3-hydroxybutyrate was prepared following the procedure as described in step 1) of Preparation Example 2, except for that isobutyl acetoacetate was used to replace for ethyl acetoacetate. Yield 52%.

後処理

customof Preparation Example 2

出典と根拠

ORDレコード: ord-80027128514a4fbeb52d0490b1fd072a
出典データセット: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07351778B2

反応ノート

読み込み中…