Diethylamine → 2-Chloro-N,N-diethyl-4-nitrobenzeneacetamide

HRID 898550ノート

反応式

HRID 898550 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[CH2:11][C:12](Cl)=[O:13].[CH2:15]([NH:17][CH2:18][CH3:19])[CH3:16]>CCOC(C)=O>[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[CH2:11][C:12]([N:17]([CH2:18][CH3:19])[CH2:15][CH3:16])=[O:13]

参加物

4

反応物 2

HCID 8021DiethylamineHCID 85969188(2-Chloro-4-nitrophenyl)acetic acid chloride

生成物 1

HCID 688195332-Chloro-N,N-diethyl-4-nitrobenzeneacetamide

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

At 0° C. a solution of 3.20 g (13.673 mmol) (2-chloro-4-nitro-phenyl)-acetyl-chloride in 50 mL EtOAc was slowly added dropwise to a solution of 5.67 mL (54.000 mmol) diethylamine in 50 mL EtOAc, then the cooling bath was removed and the mixture was stirred for 2 h at RT . The reaction mixture was diluted with EtOAc, the org. phase was washed with water and saturated aqueous NaCl solution, dried over sodium sulphate and evaporated down i. vac.

後処理

  1. customthe cooling bath was removed
  2. additionThe reaction mixture was diluted with EtOAc
  3. washphase was washed with water and saturated aqueous NaCl solution
  4. dry with materialdried over sodium sulphate
  5. customevaporated down i

出典と根拠

ORDレコード
ord-69b4bb77ac7b4c95bc2b5c6f4c972d39
出典データセット
uspto-grants-2008_04
特許番号
US07351719B2

反応ノート

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