1-(2-Chloro-4-nitro-benzyl)-pyrrolidine → 3-Chloro-4-pyrrolidin-1-ylmethyl-phenylamine

HRID 898587ノート

反応式

HRID 898587 の反応式
[Cl:1][C:2]1[CH:13]=[C:12]([N+:14]([O-])=O)[CH:11]=[CH:10][C:3]=1[CH2:4][N:5]1[CH2:9][CH2:8][CH2:7][CH2:6]1>[Ni].CO>[Cl:1][C:2]1[CH:13]=[C:12]([NH2:14])[CH:11]=[CH:10][C:3]=1[CH2:4][N:5]1[CH2:6][CH2:7][CH2:8][CH2:9]1

参加物

4

反応物 1

HCID 576632361-(2-Chloro-4-nitro-benzyl)-pyrrolidine

生成物 1

HCID 287218273-Chloro-4-pyrrolidin-1-ylmethyl-phenylamine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

A suspension of 1.00 g (4.155 mmol) 1-(2-chloro-4-nitro-benzyl)-pyrrolidine (140a) and 100 mg Raney nickel in 30 mL MeOH were hydrogenated at RT and 10 psi. The catalyst was filtered off and the filtrate evaporated down i. vac.

後処理

  1. customwere hydrogenated at RT
  2. filtrationThe catalyst was filtered off
  3. customthe filtrate evaporated down i

出典と根拠

ORDレコード
ord-4d2e7e4ba93d4199ad52f7f75f41af8e
出典データセット
uspto-grants-2008_04
特許番号
US07351719B2

反応ノート

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