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L-Proline, ethyl ester → Ethyl (s)-1-(2-{2-chloro-4-[2-(2-chloro-4-trifluoromethyl-phenoxy)-acetylamino]-phenoxy}-ethyl)-pyrrolidine-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Proline, ethyl ester | HCID 79888 | — |
| 反応物 | N-[4-(2-bromo-ethoxy)-3-chloro-phenyl]-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide | HCID 59691643 | — |
| 生成物 | Ethyl (s)-1-(2-{2-chloro-4-[2-(2-chloro-4-trifluoromethyl-phenoxy)-acetylamino]-phenoxy}-ethyl)-pyrrolidine-2-carboxylate | HCID 59691691 | — |
反応手順
Prepared analogously to Example 145 starting from N-[4-(2-bromo-ethoxy)-3-chloro-phenyl]-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide (Z28b) and ethyl (S )-pyrrolidine-2-carboxylate
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07351719B2 |
| 出典データセット | uspto-grants-2008_04 |
| ORD ID | ord-8a44d9664f494dc58670ddfc74b77530 |
| 出典メモ | uspto-grants-2008_04 |