(E)-3-(4'-chlorobiphenyl-4-yl)-N-(4-piperidin-1-ylmethylphenyl)acrylamide → 3-(4'-Chloro-biphenyl-4-yl)-n-(4-piperidin-1-ylmethyl-phenyl)-propionamide

HRID 898619ノート

反応式

HRID 898619 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11](/[CH:14]=[CH:15]/[C:16]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([CH2:25][N:26]4[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]4)=[CH:21][CH:20]=3)=[O:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1>[Ni].CCOC(C)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][CH2:15][C:16]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([CH2:25][N:26]4[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]4)=[CH:21][CH:20]=3)=[O:17])=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 9980157(E)-3-(4'-chlorobiphenyl-4-yl)-N-(4-piperidin-1-ylmethylphenyl)acrylamide

生成物 1

HCID 596915573-(4'-Chloro-biphenyl-4-yl)-n-(4-piperidin-1-ylmethyl-phenyl)-propionamide

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 8857Ethyl Acetate溶媒

実験手順

A suspension of 0.200 g (0.464 mmol) (E)-3-(4′-chloro-biphenyl-4-yl)-N-(4-piperidin-1-ylmethyl-phenyl)-acrylamide (Example 172) and 100 mg Raney nickel in 50 mL EtOAc was hydrogenated at RT and 50 psi. The catalyst was filtered off, the filtrate was evaporated down i. vac. and the residue was triturated with ether. The precipitate was filtered off, washed with ether and dried at 50° C. i. vac.

後処理

  1. customwas hydrogenated at RT
  2. filtrationThe catalyst was filtered off
  3. customthe filtrate was evaporated down i
  4. customand the residue was triturated with ether
  5. filtrationThe precipitate was filtered off
  6. washwashed with ether
  7. customdried at 50° C. i

出典と根拠

ORDレコード
ord-41e9c4842206472690400c5b667e3bb9
出典データセット
uspto-grants-2008_04
特許番号
US07351719B2

反応ノート

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