HCID 5709520、化合物 → HCID 59691545、化合物

反応式

[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1/[CH:12]=[CH:13]/[C:14]([OH:16])=O.[Cl:17][C:18]1[CH:19]=[C:20]([NH2:32])[CH:21]=[CH:22][C:23]=1[CH2:24][N:25]1[CH2:30][CH2:29][CH:28]([CH3:31])[CH2:27][CH2:26]1>>[Cl:17][C:18]1[CH:19]=[C:20]([NH:32][C:14](=[O:16])/[CH:13]=[CH:12]/[C:3]2[CH:4]=[CH:5][C:6]([C:8]([F:9])([F:10])[F:11])=[CH:7][C:2]=2[Cl:1])[CH:21]=[CH:22][C:23]=1[CH2:24][N:25]1[CH2:26][CH2:27][CH:28]([CH3:31])[CH2:29][CH2:30]1

参加物

反応物 2

HCID 5709520HCID 5709520、化合物

HCID 287218443-Chloro-4-(4-methyl-piperidin-1-ylmethyl)-phenylamine

生成物 1

HCID 59691545HCID 59691545、化合物

実験手順

Prepared analogously to Example 143 starting from (E)-3-(2-chloro-4-trifluoromethyl-phenyl)-acrylic acid (Z37b) and 3-chloro-4-(4-methyl-piperidin-1-ylmethyl)-phenylamine (Z36b). The crude product was purified by column chromatography (Alox, neutral, act. II-III, petroleum ether/EtOAc 3:1).

後処理

customThe crude product was purified by column chromatography (Alox, neutral, act. II-III, petroleum ether/EtOAc 3:1)

出典と根拠

ORDレコード: ord-f15a64e1f52f4cd491e5c85ccc838b1c
出典データセット: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07351719B2

反応ノート

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