(2-Chloro-4-trifluoromethyl-phenoxy)-acetic acid → n-[3-Chloro-4-(2-diethylamino-ethyl)-phenyl]-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide

HRID 898632ノート

反応式

HRID 898632 の反応式
[Cl:1][C:2]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][C:6]([OH:8])=O.[Cl:17][C:18]1[CH:19]=[C:20]([NH2:31])[CH:21]=[CH:22][C:23]=1[CH2:24][CH2:25][N:26]([CH2:29][CH3:30])[CH2:27][CH3:28]>>[Cl:17][C:18]1[CH:19]=[C:20]([NH:31][C:6](=[O:8])[CH2:5][O:4][C:3]2[CH:9]=[CH:10][C:11]([C:13]([F:16])([F:15])[F:14])=[CH:12][C:2]=2[Cl:1])[CH:21]=[CH:22][C:23]=1[CH2:24][CH2:25][N:26]([CH2:29][CH3:30])[CH2:27][CH3:28]

参加物

3

反応物 2

HCID 59691547(2-Chloro-4-trifluoromethyl-phenoxy)-acetic acidHCID 596916173-Chloro-4-(2-diethylaminoethyl)phenylamine

生成物 1

HCID 10073080n-[3-Chloro-4-(2-diethylamino-ethyl)-phenyl]-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide

実験手順

Prepared analogously to Example 143 starting from (2-chloro-4-trifluoromethyl-phenoxy)-acetic acid (Z2b) and 3-chloro-4-(2-diethylamino-ethyl)-phenylamine (Z44d). The reaction mixture was poured onto ice water and the aqueous phase was extracted with EtOAc. The org. phase was dried over sodium sulphate and evaporated down i. vac. The residue was purified by column chromatography (Alox, neutral, act. II-III, gradient petroleum ether/EtOAc 5:2→1:1).

後処理

  1. additionThe reaction mixture was poured onto ice water
  2. extractionthe aqueous phase was extracted with EtOAc
  3. dry with materialphase was dried over sodium sulphate
  4. customevaporated down i
  5. customThe residue was purified by column chromatography (Alox, neutral, act. II-III, gradient petroleum ether/EtOAc 5:2→1:1)

出典と根拠

ORDレコード
ord-de032a7c47c9431a9127f7dd7c236cf7
出典データセット
uspto-grants-2008_04
特許番号
US07351719B2

反応ノート

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