Potassium Carbonate → HCID 59692072、化合物

HRID 898674ノート

反応式

HRID 898674 の反応式
C[Si](C#CC1C=C2C(=CC=1)OC(C)(C)CC2(C)C)(C)C.C[Si]([C:25]#[C:26][C:27]1[CH:28]=[C:29]2[C:34](=[C:35]([CH:37]=[O:38])[CH:36]=1)[O:33][C:32]([CH3:40])([CH3:39])[CH2:31][C:30]2([CH3:42])[CH3:41])(C)C.C(=O)([O-])[O-].[K+].[K+]>CO>[C:26]([C:27]1[CH:28]=[C:29]2[C:34](=[C:35]([CH:37]=[O:38])[CH:36]=1)[O:33][C:32]([CH3:40])([CH3:39])[CH2:31][C:30]2([CH3:42])[CH3:41])#[CH:25]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 596920816-Trimethlsilanylethynyl-2,2,4,4-tetramethyl chroman-8-carbaldehydeHCID 69216465trimethyl-[2-(2,2,4,4-tetramethyl-3H-chromen-6-yl)ethynyl]silane

生成物 1

HCID 59692072HCID 59692072、化合物収率 85%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 6-trimethylsilanylethynyl-2,2,4,4-tetramethyl chroman (Compound 43, 1.78 g, 5.4 mmol) in methanol (20 mL) was treated with potassium carbonate (0.745 g, 5.4 mmol) and the resulting reaction mixture was stirred at ambient temperature for 3 h. The reaction mixture was filtered, the filtrate was evaporated in vacuo and the residue was subjected to flash column chromatography over silica gel (230-400 mesh) using 2-5% ethyl acetate in hexane as the eluent to afford the title compound (1.1 g, 85%).

後処理

  1. customthe resulting reaction mixture
  2. filtrationThe reaction mixture was filtered
  3. customthe filtrate was evaporated in vacuo

出典と根拠

ORDレコード
ord-b987f7c7be584d95a9cc8e28a92f5996
出典データセット
uspto-grants-2008_04
特許番号
US07351737B2

反応ノート

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