Triethylamine → HCID 59692068、化合物

HRID 898675ノート

反応式

HRID 898675 の反応式
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[C:11]([CH:13]=[O:14])[CH:12]=1)[O:9][C:8]([CH3:16])([CH3:15])[CH2:7][C:6]2([CH3:18])[CH3:17])#[CH:2].[CH3:19][O:20][C:21](=[O:30])[CH2:22][C:23]1[CH:28]=[CH:27][C:26](I)=[CH:25][CH:24]=1.C(N(CC)CC)C.C(OCC)(=O)C>CCCCCC.[Cu]I.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH3:19][O:20][C:21](=[O:30])[CH2:22][C:23]1[CH:24]=[CH:25][C:26]([C:2]#[C:1][C:3]2[CH:4]=[C:5]3[C:10](=[C:11]([CH:13]=[O:14])[CH:12]=2)[O:9][C:8]([CH3:16])([CH3:15])[CH2:7][C:6]3([CH3:18])[CH3:17])=[CH:27][CH:28]=1

参加物

8

反応物 4

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 10378700Methyl 4-IodophenylacetateHCID 59692072HCID 59692072、化合物2 回

生成物 1

HCID 59692068HCID 59692068、化合物

試薬・触媒・溶媒 3

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)触媒HCID 178418476HCID 178418476、化合物触媒HCID 8058Hexane溶媒

実験手順

Following general procedure J and using 6-ethynyl-2,2,4,4-tetramethyl chroman-8-carbaldehyde (Compound 44, 0.39 g, 1.61 mmol), 4-iodo phenyl acetic acid methyl ester (0.444 g, 1.61 mmol), triethyl amine (10 mL), copper(I)iodide (0.025 g, 0.13 mmol) and dichlorobis(triphenylphosphine)palladium(II) (0.090 g, 0.13 mmol) followed by flash column chromatography over silica gel (230-400 mesh) using 5-20% ethyl acetate in hexane as the eluent the title compound was obtained as an oil (0.5 g, 80%).

出典と根拠

ORDレコード
ord-2e4df7ad403245ba8c4c148d49826043
出典データセット
uspto-grants-2008_04
特許番号
US07351737B2

反応ノート

読み込み中…