Bromine → 4-Bromomethyl-5-propyl-6-chloro-pyrimidine
反応式
[Br:1]Br.[Cl:3][C:4]1[C:9]([CH2:10][CH2:11][CH3:12])=[C:8]([CH3:13])[N:7]=[CH:6][N:5]=1>CC(O)=O>[Br:1][CH2:13][C:8]1[C:9]([CH2:10][CH2:11][CH3:12])=[C:4]([Cl:3])[N:5]=[CH:6][N:7]=1参加物
4
反応条件
- 温度
- 85 °C
実験手順
Br2 (0.153 ml, 3 mmol) is added dropwise to a solution of 4-chloro-6-methyl-5-propyl-pyrimidine (3 mmol) heated at 85° C. in HOAc (10 ml). After the addition, the mixture is stirred at 85° C. for 1 hour. The solvent is removed in vacuo and the residue dissolved in EtOAc (15 ml), washed with Na2S2O3 solution (sat. 5 ml), followed by NaHCO3 (10 ml), and brine (10 ml). The organic phase is dried (Na2SO4) and evaporated. The resulting yellow oil is purified by flash column chromatography, which provides the title compound.
後処理
- additionAfter the addition
- customThe solvent is removed in vacuo
- dissolutionthe residue dissolved in EtOAc (15 ml)
- washwashed with Na2S2O3 solution (sat. 5 ml)
- dry with materialThe organic phase is dried (Na2SO4)
- customevaporated
- customThe resulting yellow oil is purified by flash column chromatography, which
出典と根拠
- ORDレコード
- ord-de3ee40559ca4a96873748834613235b
- 出典データセット
- uspto-grants-2008_04
- 特許番号
- US07351826B2
反応ノート
読み込み中…