Water → Perindopril erbumine monohydrate

HRID 898741

反応式

HRID 898741 の反応式
[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29].[OH2:32]>CC(C)=O>[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29].[OH2:32]

参加物

4

反応物 2

HCID 962WaterHCID 441313Perindopril Erbumine

生成物 1

HCID 9847044Perindopril erbumine monohydrate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Perindopril erbumine (10 gms) was suspended in acetone (80 ml). To this was added water (0.4 ml) and the contents heated to dissolve the solids and cooled to ambient. The resulting slurry was filtered to obtain perindopril erbumine monohydrate (9.4 gms).

後処理

  1. temperaturethe contents heated
  2. dissolutionto dissolve the solids
  3. temperaturecooled
  4. filtrationThe resulting slurry was filtered

出典と根拠

ORDレコード
ord-274ca6923c744e3db9f70350da48dd55
出典データセット
uspto-grants-2008_04
特許番号
US07351840B2

関連ノート

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