244205-60-5 → 1-Amino-2-phenylcyclopropane-1-carboxylic acid

HRID 898860ノート

反応式

HRID 898860 の反応式
C(OC([NH:8][C@:9]1([C:18]([OH:20])=[O:19])[CH2:11][C@H:10]1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=O)(C)(C)C.Cl.O1CCOCC1>C(OCC)C>[NH2:8][C@@:9]1([C:18]([OH:20])=[O:19])[CH2:11][C@@H:10]1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

4

反応物 2

HCID 2734148244205-60-5HCID 204431481,4-Dioxane hydrochloride

生成物 1

HCID 1338301-Amino-2-phenylcyclopropane-1-carboxylic acid収率 101.6%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To commercially available (1R,2S)-1-tert-butoxycarbonylamino-2-phenylcyclopropanecarboxylic acid (130 mg, 0.45 mmol) was added 4N hydrochloric acid—1,4-dioxane solution (2.0 mL, 16 v/w) and the mixture was stirred for 1 hr at room temperature. Diethyl ether (1.0 mL) was added thereto and the mixture was stirred for 5 min, after which the resulting crystals were collected by filtration. The crystals were washed with diethyl ether (1.0 mL) and dried under reduced pressure to give the title compound (81 mg, white powder, yield 84%).

後処理

  1. stirringthe mixture was stirred for 5 min
  2. filtrationafter which the resulting crystals were collected by filtration
  3. washThe crystals were washed with diethyl ether (1.0 mL)
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-afd4e59a7c8a428b82db1d71553f88a6
出典データセット
uspto-grants-2008_04
特許番号
US07351825B2

反応ノート

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