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Aluminium lithium hydride → rac-tert-butyl N-[(1r,4r)-4-formylcyclohexyl]carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 反応物 | Tert-butyl trans-4-(N-methoxy-N-methylcarbamoyl)cyclohexylcarbamate | HCID 24720928 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | rac-tert-butyl N-[(1r,4r)-4-formylcyclohexyl]carbamate | HCID 11020615 | 105.8% |
反応手順
[4-(Methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester (7.50 g, 26.2 mmol) in dry ether (150 ml) was reduced with an excess LiAlH4. The reaction mixture was quenched by careful addition of water and extracted with CHCl3. The mixture was dried and concentrated under reduced pressure to give (4-formyl-cyclohexyl)-carbamic acid tert-butyl ester (6.30 g, 93%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07354895B1 |
| 出典データセット | uspto-grants-2008_04 |
| ORD ID | ord-4d93907370f845c88920ef53642a78fa |
| 出典メモ | uspto-grants-2008_04 |