Hydrochloric Acid → N-[3-(4-Cyanophenyl)propyl]-N-[2-(9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl)ethyl]methanesulfonamide, hydrochloride salt

HRID 899119ノート

反応式

HRID 899119 の反応式
C(OC([N:8]1[CH2:15][CH:14]2[O:16][CH:10]([CH2:11][N:12]([CH2:17][CH2:18][N:19]([CH2:24][CH2:25][CH2:26][C:27]3[CH:32]=[CH:31][C:30]([C:33]#[N:34])=[CH:29][CH:28]=3)[S:20]([CH3:23])(=[O:22])=[O:21])[CH2:13]2)[CH2:9]1)=O)(C)(C)C.[ClH:35]>C(OCC)(=O)C>[ClH:35].[C:33]([C:30]1[CH:31]=[CH:32][C:27]([CH2:26][CH2:25][CH2:24][N:19]([CH2:18][CH2:17][N:12]2[CH2:13][CH:14]3[O:16][CH:10]([CH2:9][NH:8][CH2:15]3)[CH2:11]2)[S:20]([CH3:23])(=[O:22])=[O:21])=[CH:28][CH:29]=1)#[N:34]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 690720537-(2-{[3-(4-Cyanophenyl)propyl]methanesulfonylamino}ethyl)-9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester

生成物 1

HCID 69077585N-[3-(4-Cyanophenyl)propyl]-N-[2-(9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl)ethyl]methanesulfonamide, hydrochloride salt

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

7-(2-{[3-(4-cyanophenyl)propyl]methanesulfonylamino}ethyl)-9-oxa-3,7-di-azabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester (3.8 g, 0.0095 mol; see step (i) above) was added to a saturated solution of HCl(g) in ethyl acetate (50 mL) and the resultant mixture was then stirred overnight. On completion of the reaction (as determined by TLC), ethyl acetate was decanted and the product was dried under high vacuum to give the title compound. Yield: 1.5 g (54%).

後処理

  1. customwas decanted
  2. customthe product was dried under high vacuum

出典と根拠

ORDレコード
ord-409804f3bba5495a8605586aa564ed97
出典データセット
uspto-grants-2008_04
特許番号
US07354917B2

反応ノート

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