N,N'-Dimethylurea → 1-[2-(4-Cyanophenoxy)ethyl]-1-(2-hydroxyethyl)-3-methylurea
反応式
[OH:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][O:7][C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][CH:9]=1.[CH3:16][NH:17][C:18](NC)=[O:19]>>[C:12]([C:11]1[CH:10]=[CH:9][C:8]([O:7][CH2:6][CH2:5][N:4]([CH2:3][CH2:2][OH:1])[C:18]([NH:17][CH3:16])=[O:19])=[CH:15][CH:14]=1)#[N:13]参加物
3
反応条件
- 温度
- 130 °C
実験手順
4-[2-(2-Hydroxyethylamino)ethoxy]benzonitrile (1 g, 0.009 mol; see Preparation C, step (ii) above) and N,N′-dimethylurea (0.43 g, 0.0049 mol) were heated with stirring at 130° C. for 4 h. The reaction was directly purified by column chromatography to yield 0.7 g of the sub-title product as an off white solid.
後処理
- customThe reaction was directly purified by column chromatography
出典と根拠
- ORDレコード
- ord-3fcf4dca27f5419886967d6770579a05
- 出典データセット
- uspto-grants-2008_04
- 特許番号
- US07354917B2
反応ノート
読み込み中…