Stannous chloride dihydrate → 4'-Amino-N-isopropylbiphenyl-4-sulfonamide

HRID 899178ノート

反応式

HRID 899178 の反応式
O.O.[Sn](Cl)Cl.[CH:6]([NH:9][S:10]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][C:22]([N+:25]([O-])=O)=[CH:21][CH:20]=2)=[CH:15][CH:14]=1)(=[O:12])=[O:11])([CH3:8])[CH3:7]>CN(C=O)C>[NH2:25][C:22]1[CH:23]=[CH:24][C:19]([C:16]2[CH:17]=[CH:18][C:13]([S:10]([NH:9][CH:6]([CH3:8])[CH3:7])(=[O:12])=[O:11])=[CH:14][CH:15]=2)=[CH:20][CH:21]=1

参加物

4

反応物 2

HCID 61436Stannous chloride dihydrateHCID 59694089N-Isopropyl-4'-nitrobiphenyl-4-sulfonamide

生成物 1

HCID 596940904'-Amino-N-isopropylbiphenyl-4-sulfonamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

288.8 mg (1.28 mmol) of tin(II) chloride dihydrate are added to a solution of 100 mg (0.26 mmol) of N-isopropyl-4′-nitrobiphenyl-4-sulfonamide (Example 11A) in 2.0 ml of DMF. After 18 h at room temperature, the reaction mixture is purified by preparative HPLC. The product fractions are concentrated in vacuo and dried under high vacuum. 47 mg (63.2% of theory) of the title compound are obtained.

後処理

  1. customthe reaction mixture is purified by preparative HPLC
  2. concentrationThe product fractions are concentrated in vacuo
  3. customdried under high vacuum

出典と根拠

ORDレコード
ord-6c507e1ed79f4d77b2913042020f0f9c
出典データセット
uspto-grants-2008_04
特許番号
US07354930B2

反応ノート

読み込み中…