5-Bromo-2-fluorobenzaldehyde → 5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine

反応式

C[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]3[S:15][C:14]([NH2:16])=[N:13][N:12]=3)[CH:9]=2)[NH:4][N:3]=1.BrC1C=CC(F)=C(C=1)C=O>>[NH:4]1[C:5]2[C:10](=[CH:9][C:8]([C:11]3[S:15][C:14]([NH2:16])=[N:13][N:12]=3)=[CH:7][CH:6]=2)[CH:2]=[N:3]1

参加物

反応物 2

HCID 7363275-Bromo-2-fluorobenzaldehyde

HCID 1784342715-(3-Methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine

生成物 1

HCID 670917415-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine

実験手順

5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine was synthesized in a way similar to that of 4f as shown in Scheme 3 with commercially available 5-bromo-2-fluorobenzaldehyde as the starting material in three steps. MS (API-ES) m/z (%): 218 (100%, M++1).

出典と根拠

ORDレコード: ord-cece80de08784bbbaa21c363afd0962f
出典データセット: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07354944B2

反応ノート

読み込み中…