Acetic Anhydride → HCID 178475126、化合物

HRID 899418ノート

反応式

HRID 899418 の反応式
[CH3:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([CH:11]=[N:12][NH:13][C:14]([NH2:16])=[S:15])[CH:9]=2)[NH:4][N:3]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[C:17]([NH:16][C:14](=[N:13]/[N:12]=[CH:11]/[C:8]1[CH:9]=[C:10]2[C:2]([CH3:1])=[N:3][NH:4][C:5]2=[N:6][CH:7]=1)[SH:15])(=[O:19])[CH3:18]

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 178434443HCID 178434443、化合物

生成物 1

HCID 178475126HCID 178475126、化合物

反応条件

温度
80 °C

実験手順

The staring material 1-((3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methylene)thiosemicarbazide (500 mg, 2.0 mmol) and acetic anhydride (20 ml) was mixed and heated to 80° C. for 1 hour. The reaction mixture was then cooled down to room temperature. The yellow solid was precipitated out and was filtered off. The yellow solid was washed with ether (50 ml). The product was obtained in quantitative yield and used for the next step without further purification.

後処理

  1. temperatureThe reaction mixture was then cooled down to room temperature
  2. customThe yellow solid was precipitated out and
  3. filtrationwas filtered off
  4. washThe yellow solid was washed with ether (50 ml)
  5. customThe product was obtained in quantitative yield
  6. customused for the next step without further purification

出典と根拠

ORDレコード
ord-89f23f75c9004a259fc5c6b7252ec4b2
出典データセット
uspto-grants-2008_04
特許番号
US07354944B2

反応ノート

読み込み中…