4-Pyridinecarboxaldehyde → HCID 10346809、化合物

HRID 899944

反応式

HRID 899944 の反応式
[NH:1]([C:8](OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=[O:9])[C@H:2]([C:5]([OH:7])=[O:6])[CH2:3][OH:4].[N:25]1[CH:30]=[CH:29][C:28]([CH:31]=O)=[CH:27][CH:26]=1.[F:33][C:34]([F:46])([F:45])[S:35]([C:38]1[CH:44]=[CH:43][C:41]([NH2:42])=[CH:40][CH:39]=1)(=[O:37])=[O:36]>>[F:33][C:34]([F:46])([F:45])[C:5]([OH:7])=[O:6].[CH3:5][C@@H:2]1[N:1]([CH2:31][C:28]2[CH:27]=[CH:26][N:25]=[CH:30][CH:29]=2)[C:8](=[O:9])[N:42]([C:41]2[CH:43]=[CH:44][C:38]([S:35]([C:34]([F:45])([F:33])[F:46])(=[O:36])=[O:37])=[CH:39][CH:40]=2)[C:3]1=[O:4]

参加物

4

反応物 3

HCID 133894-PyridinecarboxaldehydeHCID 1363154-Aminophenyl trifluoromethyl sulphoneHCID 6541433(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-hydroxypropanoic acid

生成物 1

HCID 10346809HCID 10346809、化合物

実験手順

The compound is prepared from 0.025 mmol of resin, 0.075 mmol of N-Fmoc-L-Ala(OH), 0.125 mmol of 4-pyridinecarboxaldehyde and 0.0625 mmol of 4-(trifluoromethanesulfonyl)aniline, in the same way as in Example 1. After purification by preparative LC-MS, 5.6 mg of expected product are obtained.

後処理

  1. customAfter purification by preparative LC-MS, 5.6 mg of expected product
  2. customare obtained

出典と根拠

ORDレコード
ord-4cfcd7e6d3f3419ba4d3c2ed245ed402
出典データセット
uspto-grants-2008_04
特許番号
US07354933B2

関連ノート

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