Triethylamine → 4-(Chloromethyl)-6-methoxy-quinoline
反応式
C(N(CC)CC)C.CS([Cl:12])(=O)=O.O[CH2:14][C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([O:25][CH3:26])[CH:23]=2)[N:18]=[CH:17][CH:16]=1>ClCCl>[Cl:12][CH2:14][C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([O:25][CH3:26])[CH:23]=2)[N:18]=[CH:17][CH:16]=1参加物
5
実験手順
1.16 ml of triethylamine and 0.64 ml of methanesulfonyl chloride are successively added to a solution of 1.2 g of 4-hydroxymethyl-6-methoxyquinoline in 45 ml of dichloromethane, under an inert atmosphere of argon at a temperature in the region of 20° C. Stirring is maintained at this temperature for 3 hours. The reaction medium is concentrated under reduced pressure to give a brown residue. The product is used without further purification in the following step.
後処理
- temperatureis maintained at this temperature for 3 hours
- concentrationThe reaction medium is concentrated under reduced pressure
- customto give a brown residue
- customThe product is used without further purification in the following step
出典と根拠
- ORDレコード
- ord-a487fe5f261f4611a7f4ef14eca8da73
- 出典データセット
- uspto-grants-2008_04
- 特許番号
- US07354933B2
反応ノート
読み込み中…